Chronic histiocytic intervillositis (CHI) is a rare placental disorder that affects approximately 1 in 600 pregnancies.1 It is diagnosed when at least 5% of the intervillous space is occupied by maternal CD68+ immune cells (histiocytes) and is often accompanied by massive perivillous fibrin deposition.2 CHI is strongly associated with miscarriage (24%), stillbirth (29%), fetal growth restriction (72%) and […]
Author: kaosfusion
Chronic intervillositis of unknown etiology (CIUE) is a rare, poorly understood, histopathological diagnosis of the placenta that is frequently accompanied by adverse pregnancy outcomes including miscarriage, fetal growth restriction, and intrauterine fetal death. CIUE is thought tohave an immunologically driven pathophysiology and may be related to human leukocyte antigen mismatches between the mother and the […]
Abstract: Chronic histiocytic intervillositis of the placenta (CHI) is a rare and potentially recurrent disease. Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta. Methods: We analysed the expression profile of 102 inflammation- […]
Letter to the Editor (case report) SIR, Chronic intervillositis is a rare and poorly understood disease characterized by intervillous infiltrates of maternal origin. The intervillositis infiltrates from mononuclear cells (monocytes, histiocytes) correlate with placental insufficiency, and result in intrauterine growth restriction, intrauterine fetal death and spontaneous miscarriage [1]. Chronic intervillositis aetiology is not well established. […]
DIAGNOSES: Intrauterine fetal demise (second trimester). Diffuse villous fibrosis, perivillous and intravillous fibrin deposition associated with chronic villitis and intervillositis (placentitis), histiocytic type. Influenza A virus infection (type not specified) with ultrastructural, immunohistochemical, and PCR confirmation. CASE 2: Fetal Demise Associated With Influenza A Infection. Richard Lieberman, MD
Context.—Chronic histiocytic intervillositis is an uncommon and poorly recognized lesion associated with poor perinatal outcomes, including intrauterine growth retardation and stillbirth. It has a high recurrence rate. Objective.—To evaluate utility of CD68 immunostaining in the evaluation of chronic histiocytic intervillositis. Design.—Institutional review board–approved retrospective review was performed. Cases were selected from the departmental archives of […]
ABSTRACT Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in […]
Summary (translation from the original paper in French): We report the cases of two patients who had a favourable outcome with aspirin and corticosteroid therapy during pregnancy for chronic villitis of unknown etiology complicated by labor asphyxia and further intrauterine fetal demise in one gravida 3 patient and for chronic intervillositis of unknown etiology diagnosed […]
RÉSUMÉ- Article en Français Les auteurs rapportent les résultats favorables obtenus en cours de grossesse par l’association aspirine et corticoïdes, d’une part, chez une patiente troisième geste ayant présenté des lésions placentaires de villite chronique d’étiologie indé- terminée, compliquée d’une asphyxie fœtale pendant le travail, puis d’une mort in utero, d’autre part, chez une quatrième […]
