Fetal death in primary Sjögren’s syndrome (SS) associated with chronic intervillositis. Arsene Mekinian

Letter to the Editor (case report)

SIR, Chronic intervillositis is a rare and poorly understood disease characterized by intervillous infiltrates of maternal origin. The intervillositis infiltrates from mononuclear cells (monocytes, histiocytes) correlate with placental insufficiency, and result in intrauterine growth restriction, intrauterine fetal death and spontaneous miscarriage [1]. Chronic intervillositis aetiology is not well established. Recent physiopathological studies have argued in favour of an immune response resulting from an abnormal maternal reaction to the placental tissue, which could preferentially implicate T-lymphocytes. Thus chronic intervillositis could be associated with auto- immune diseases, such as antiphospholipid syndrome (APS), but its association with other autoimmune disorders has not yet been determined [2]. We describe the case of a pregnant woman with underlying primary Sjögren’s syndrome (SS) who presented intrauterine fetal death in relation with chronic intervillositis of the placenta.

Fetal death in primary Sjögren’s syndrome (SS) associated with chronic intervillositis. Arsene Mekinian

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