RÉSUMÉ- Article en Français
Les auteurs rapportent les résultats favorables obtenus en cours de grossesse par l’association aspirine et corticoïdes, d’une part, chez une patiente troisième geste ayant présenté des lésions placentaires de villite chronique d’étiologie indé- terminée, compliquée d’une asphyxie fœtale pendant le travail, puis d’une mort in utero, d’autre part, chez une quatrième geste atteinte d’intervillite chronique d’étiologie indéterminée découverte après trois morts périnatales. Dans la littérature, la villite chronique d’étiologie indéterminée (CVUE) est retrouvée dans 7 à 33 % des placentas, notamment lors de retards de croissance intra-utérins (RCIU) « idiopathiques », de prématurités inexpliquées, de pré-éclampsies, d’asphyxies fœtales et de morts in utero. L’intervillite chronique d’étiologie indéterminée (CIUE), beaucoup plus rare (0,6 à 0,9/1000), a été incriminée dans les accidents gravidiques à répétition, fausses couches, RCIU et morts in utero. L’aspect histologique de ces lésions inflammatoires chroniques du placenta et l’étude immuno-histochimique évoquent un conflit immunologique sous la forme d’un rejet de l’allogreffe de la grossesse. L’effet favorable de la corticothérapie (prednisone) associée à l’aspirine doit être confirmé par des séries plus importantes.
Mots-clés : Villite chronique d’étiologie indéterminée • Intervillite chronique d’étiologie indéterminée • Accidents périnatals
à répétition • Aspirine • Corticoïdes.
NB: This article is in French. If you would like to read the same article in English refer to: Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology: G. Boog, C. Le Vaillant, F. Alnoukari, F. Jossic, J. Barrier, J.-Y. Muller
64 replies on “Association des corticoïdes à l’aspirine pour la prévention des récidives de villite ou d’intervillite chroniques d’étiologie indéterminée”
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