Categories
Medical Research

Expression analysis of leukocytes attracting cytokines in chronic histiocytic intervillositis of the placenta: Freitag, von Kaisenberg, Kreipe, Hussein

Abstract: Chronic histiocytic intervillositis of the placenta (CHI) is a rare and potentially recurrent disease. Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta. Methods: We analysed the expression profile of 102 inflammation- […]

Categories
Medical Research

Fetal death in primary Sjögren’s syndrome (SS) associated with chronic intervillositis. Arsene Mekinian

Letter to the Editor (case report) SIR, Chronic intervillositis is a rare and poorly understood disease characterized by intervillous infiltrates of maternal origin. The intervillositis infiltrates from mononuclear cells (monocytes, histiocytes) correlate with placental insufficiency, and result in intrauterine growth restriction, intrauterine fetal death and spontaneous miscarriage [1]. Chronic intervillositis aetiology is not well established. […]

Categories
Medical Research

Fetal Demise Associated With Influenza A Infection. Richard Lieberman, MD

DIAGNOSES: Intrauterine fetal demise (second trimester). Diffuse villous fibrosis, perivillous and intravillous fibrin deposition associated with chronic villitis and intervillositis (placentitis), histiocytic type. Influenza A virus infection (type not specified) with ultrastructural, immunohistochemical, and PCR confirmation. CASE 2: Fetal Demise Associated With Influenza A Infection. Richard Lieberman, MD

Categories
Medical Research

CD68 Immunostaining in the Evaluation of Chronic Histiocytic Intervillositis. Debra S. Heller, MD

Context.—Chronic histiocytic intervillositis is an uncommon and poorly recognized lesion associated with poor perinatal outcomes, including intrauterine growth retardation and stillbirth. It has a high recurrence rate. Objective.—To evaluate utility of CD68 immunostaining in the evaluation of chronic histiocytic intervillositis. Design.—Institutional review board–approved retrospective review was performed. Cases were selected from the departmental archives of […]

Categories
Medical Research

Co-occurrence of Massive Perivillous Fibrin Deposition and Chronic Intervillositis: Case Report

ABSTRACT Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in […]

Categories
Medical Research

Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology

Summary (translation from the original paper in French): We report the cases of two patients who had a favourable outcome with aspirin and corticosteroid therapy during pregnancy for chronic villitis of unknown etiology complicated by labor asphyxia and further intrauterine fetal demise in one gravida 3 patient and for chronic intervillositis of unknown etiology diagnosed […]

Categories
Medical Research

Association des corticoïdes à l’aspirine pour la prévention des récidives de villite ou d’intervillite chroniques d’étiologie indéterminée

RÉSUMÉ- Article en Français Les auteurs rapportent les résultats favorables obtenus en cours de grossesse par l’association aspirine et corticoïdes, d’une part, chez une patiente troisième geste ayant présenté des lésions placentaires de villite chronique d’étiologie indé- terminée, compliquée d’une asphyxie fœtale pendant le travail, puis d’une mort in utero, d’autre part, chez une quatrième […]