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Medical Research

Massive perivillous fibrin deposition and chronic intervillositis: frequently missed diagnoses with a high recurrence risk: MA Weber, PGJ Nikkels, KE Hamoen, JJ Duvekot, RR de Krijger

This study talks about MFD/MFI and CI as similar conditions both of which are very rare. It looks at one case study and talks about how the diseases may be similar. It mentions heparin-type drugs and immunosuppresants as possible treatment options. Its focus is to encourage better diagnosis of this condition to improve standards of […]

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Medical Research

Chronic villitis in untreated neonatal alloimmune thrombocytopenia: An etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy.

This study looks at CHIV in the specific case of neonatal alloimmune thrombocytopenia. It suggests that intravenous immunoglobulin given to the mother may help improve the outcome although the results weren’t statistically significant because there weren’t enough case studies. Chronic villitis in untreated neonatal alloimmune thrombocytopenia: An etiology for severe early intrauterine growth restriction and […]

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Medical Research

Massive Chronic Intervillositis Associated With Recurrent Abortions: Barbara J. Doss

This covers a specific case of MCI/CHIV in a lady who had 10 recurrent miscarriages in her first and second trimesters (although she also had two live births as well!). They look at each pregnancy and try to find similarities and differences between them. Other than that, it draws many similar conclusions as other studies. […]

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Medical Research

A combination treatment of prednisone, aspirin, folate, and progesterone in women with idiopathic recurrent miscarriage: a matched-pair study Clemens B. Tempfer, M.D. et al

This study looks at a treatment in the form of prednisone, aspirin, folate, and progesterone in women who had suffered from more than three miscarriages. It found a statistically significant and positive effect in treating women with this regimen compared to those who weren’t treated. The comment on the study is about how valuable the […]

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Medical Research

The placenta in preterm birth: O M Faye-Petersen (2008)

This is a general paper for pathologists who may need to give a report on a preterm placenta. It talks about lots of different types of issues with placentas and covers of CVUE or VUA as it calls it and also mentions MCI but only very briefly. The placenta in preterm birth: O M Faye-Petersen […]

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Medical Research

Prevalence of Developmental and Inflammatory Lesions in Nonmolar First-Trimester Spontaneous Abortions: Raymond W, Redline, MD, Michael Zaragoza, and Terry Hassold, PhD

This study concentrates only on first trimester miscarriages. It identifies CHIV/MCI as one of the features that shows up when the fetus does not appear to have DNA problems (has normal karotypes) and yet a miscarriage took place. Prevalence of Developmental and Inflammatory Lesions in Nonmolar First-Trimester Spontaneous Abortions: Raymond W, Redline, MD, Michael Zaragoza, […]

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Medical Research

Placental Pathology, a Survival Guide: Drucilla J Roberts (2008)

This describes the processes involved in looking at the placenta to determine possible issues. It talks about CHIV/MCI and how the placenta may look if you have it. It also talks about how MCI can be a placental cause of elevated maternal serum α-fetoprotein. Placental Pathology, a Survival Guide: Drucilla J Roberts (2008)

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Medical Research

Placental pathology of recurrent spontaneous abortion – the role of histopathological examination of products of conception in routine clinical practice: a mini review: P.Jindal et al.

This looks at 12 different studies relating to pathology of placentas and fetuses after recurrent miscarriages and stillbirths and picks up on different issues that can occur including CHI. It talks about how there isn’t consistent work being done to detect issues such as CHI in pregnancies which, while very rare, is important to do […]

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Medical Research

Pronostic périnatal des grossesses compliquées d’intervillites chroniques placentaires: C. Rota, D. Carles, V. Schaeffer, F. Guyon, R. Saura, J. Horovitz

This is in French and I’m afraid my translation skills are rubbish! If anyone can offer to read and translate, that would be wonderful! Pronostic périnatal des grossesses compliquées d’intervillites chroniques placentaires: C. Rota, D. Carles, V. Schaeffer, F. Guyon, R. Saura, J. Horovitz